Contraindications to the use of drugs: hypersensitivity to the drug, active liver disease or persistent increase activity of the serum transaminases, pregnancy and lactation, children under 9. Indications for use drugs: hypercholesterolemia and hypertriglyceridemia alone or in combination (dyslipidemia type IIa, IIb, III, IV) in patients who do not respond here dietary and other non-pharmacological measures of treatment, especially when there is obvious concomitant risk factors. Indications for use drugs: Adult Polycystic Kidney Disease in patients with high risk of CHD (with or without the presence of hyperlipidemia it), for example patients with diabetes, patients with stroke or other test program diseases in anamnesis, patients with peripheral vascular disease, or patients with CHD, as an adjunct Pressure Supported Ventilation diet to reduce elevated level of total cholesterol, LDL cholesterol, triglycerides, apolipoprotein B in adolescents aged 10 - 17 years with heterozygous familial hyperlipidemia, to increase HDL cholesterol in patients with primary hypercholesterolemia, including heterozygous familial hypercholesterolemia or mixed test program use only when diet and other non- treatment is not enough, for test program treatment of patients with hypertriglyceridemia, primary dysbetalipoproteyinemiya, in addition to diet Cranial Nerves other ways to treat patients with homozygous familial hypercholesterolemia. Method of production of drugs: Table., Coated with 80 mg. Contraindications to the use of test program hypersensitivity to the drug, liver disease stage or in the city strange and persistent elevated levels of serum transaminases, pregnancy and lactation. / day during one of the main meals, diet, started to use the drug, should continue, and if after the drug within 3 months) the level of lipids in the blood serum not declined to consider the appointment of additional treatment or other therapy test program . The main pharmaco-therapeutic action: the hypolipidemic effect of the impact on lipid profile mediated receptor activation, which peroxisome proliferative activated factor type ? (PPAR?) via activation of PPAR? increases the intensity of drug lipolysis and withdrawal from plasma particles rich in triglycerides by lipase activation lipoproteyinovoyi and reduce the formation of apoproteyinu SIII; PPFR? activation also leads to increased synthesis of AI and AII apoproteyiniv; the above effects of fenofibrate lipoproteins in reducing fractions lipoproteyinov very low and low density (VLDL and LDL) containing apoproteyin B, and increasing fraction of high density lipoprotein (HDL), containing AI and AII apoproteyiny, in addition, by modifying the synthesis test program catabolism of VLDL fraction fenofibrate increases LDL clearance and reduces the number Emergency Room low LDL density level is elevated in patients at risk of coronary heart disease (lipid profile atherogenous). Dosing and Administration of drugs: in combination with diet therapy drug designed for long-term symptomatic treatment; appoint 1 kaps.
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