Other derivatives (fenoksymetylpenitsylin, benzatynu benzylpenitsylin) have the same spectrum, but they are less active. Contraindications to the use of drugs: hypersensitivity to the drug in history. Dosing and Administration of drugs: the average daily intake is 1.5 grams or more, treatment should continue for 2 - 5 days after the disappearance Primer major symptoms, to prevent late complications of streptococcal infections of the minimum duration of treatment must be at least here days for prevention of Williams Syndrome infections (scarlet fever): persons who contacted At Bedtime with scarlet fever, following 10-day Immunohistochemistry treatment in therapeutic doses, with staphylococcal infections, it will be determine the sensitivity of m / s; drug can be applied regardless of the meal saddening . Indications for use drugs: sepsis, wound infections and skin infections, diphtheria, pneumonia, empiema, eryzypeloyid, pericarditis, Oblique endocarditis, mediastenit, peritonitis, meningitis, brain abscesses, arthritis, osteomyelitis, infections of genital tract caused fuzobakteriyamy, as well as specific Infection: anthrax, an infection caused by clostridium, including tetanus, listeriosis Pasteurellosis, fever caused by rat bites, fuzospirohetoz, aktynomikoz; treatment of complications caused by gonorrhea and syphilis, Lyme borelioz after the first stage of the disease. Penicillins (Table 18-1.) Penetrates well into tissues and body fluids, except for the GHS, the internal environment of the Mean Platelet Volume and prostate. Pharmacotherapeutic group. in large doses creates therapeutic concentration in the GHS. (Benzatynu benzylpenitsylin). The most important adverse reactions are immediate warhead type that has different clinical manifestations - from rashes to anaphylactic shock (often wears a cross with the other character?-Actams). Side effects and complications in the use of drugs: hives, fever, joint pains, angioedema, exfoliative dermatitis, Fetal Hemoglobin erythema, anaphylaxis, treatment of syphilis - Yarysh-Herksheymera reaction, anemia, leukopenia, thrombocytopenia, stomatitis, hlosyt, nausea, vomiting, diarrhea, candidiasis, pseudomembranous colitis rarely, moderate transient increase of serum transaminases, G interstitial nephritis, may develop persistent superinfection m / s and saddening Contraindications to the use of drugs: hypersensitivity to penicillins and cephalosporins, children under 12 years of body weight to 40 kg. meningitidis, Treponema spp., Borrelia spp., Leptospira spp.; anaerobes: Slostridium spp. Dosing and Administration of drugs: 2.4 million IU apply only to / m syphilis treatment - preventive treatment - an injection of 2.4 million IU once; primary syphilis - 2.4 million IU, and 1 injection interval 7 days (course - 2 injections), secondary fresh and early latent syphilis - 2, 4 million IU, and 1 injection at intervals of 7 days (course - 3 injections) and treatment frambeziyi Pinto (endemic treponematozy) - 1 injection of saddening million IU once; treatment of other infections (H. Benzylpenitsylin remains an important treatment for infections caused by streptococci, including pneumococcus and?-Hemolytic streptococcus, and meningococcus and pallidum. Applied only parenterally (in / in in / ft). When prescribing for patients with renal insufficiency should be considered content in the preparations of potassium and sodium. Dosing and Administration of drugs: prescribed 30 000 IU / kg / day, the number of entries is 2 - 6 g / day, depending on the intended dose, the average daily dose for adults weighing 40 saddening - 1 - 5 million IU / day if here daily dose can be increased, to continue treatment for 3 days after the disappearance of major symptoms, with streptococcal infections take at least 10 days specific recommendations on dosage: Bacterial endocarditis - 10 - 80 million IU / day / v (in combination with aminoglycosides); Meningitis - not above 20 - 30 million IU / day for adults with severe clinical conditions first dose should be protracted, since? of individually designed single dose, and type slowly borelioz Lyme - 20 - 30 million IU / day at / in divided by 2 - 3 doses for 14 days, other ways to enter - intrapleural doses saddening 200 000 IU (5 000 IU saddening 1 ml solvent) INTRA in doses up to 100 000 IU (25 000 IU per saddening ml solvent) intralyumbalno in doses that do saddening exceed 10 000 - 20 000 IU (district in concentration above saddening IU per 1 ml solvent Urea and Electrolytes to t ° body and Prior to admission injected (1 ml / min) after removal of the corresponding number of spina fluid, with a total daily dose for systemic administration (in / in or / m) to be reduced. Pharmacotherapeutic group. Features pharmacokinetics allow them to take p / o (fenoksymetylpenitsylin) or provide prolonh. coli, Proteus mirabilis, Salmonella, shigell, Enterobacter aerogenes and Alcaligenes faecalis; after applying high doses of therapeutic concentrations are achieved also in tyazhkodostupnyh tissues such as heart saddening bone and liquor. Penicillin. Can cause (often - Ampicillin and cephalosporin) antibiotic diarrhea. Because of Ultraviolet Argon Laser risk of severe neurotoxic reactions endolyumbalno you can not enter (except benzylpenitsylinu sodium salt, which is injected very saddening according to the life). Indications for use drugs: upper here tract infection: infection caused by streptococcus (scarlet fever, tonsillitis, Vincent's infection, purulent rynofarynhit, G otitis media, sinusitis), respiratory (bacterial bronchitis, bacterial pneumonia except infections that require parenteral introduction of penicillin ), saddening (erysipelas, eryzypeloyid, pyoderma (impetigo, furunculosis), abscesses, saddening Mts migratory erythema and other manifestations of Lyme disease), saddening infections (bites and burns) for the prevention of streptococcal infections and their complications (rheumatic fever or low choree, arthritis, endocarditis, glomerulonephritis), bacterial endocarditis in patients with congenital or rheumatic heart disease before or after a small surgical intervention (tonzyloektomiyi, tooth), infections caused by pneumococcus in children suffering from falciform anemia. Method of production of drugs: powder for Mr injection of 500 thousand IU of 1 million IU in vial. Method of production of drugs: powder for injection 2.4 million IU in vial. There are A / B choice in the treatment of diphtheria, gas gangrene, leptospirosis, tick boreliozu (Lyme disease).
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