3-hydroxy-30methyl-glutaryl-CoA reductase and Failure to thrive

Dosing and Administration of drugs: treatment for type 2 diabetes prescribed depending on the clinical picture of disease; starting dose is 2.5 - 5 mg / day for 15 - 30 minutes before meals, the drug is advised to take before breakfast or lunch.; Need for dose increase to 15 mg / day in 2 ways, the maximum single dose - 15 mg, MDD - 40 mg. Indications for use drugs: treatment of type 2 diabetes, with the ineffectiveness of diet and graduated exercise. with modified release: 1 Table. hliklazydu 60 mg. prolonged to 5 mg, 10 mg. Method of production of drugs: Table. to 5 mg tab. should be swallowed whole, if necessary, increase the level of glycemic control daily dose can be increased to 60 mg, 90 mg or 120 mg once during breakfast, increase in dose is recommended gradually, at intervals of 1 month, except when there was no decrease in glucose blood within 2 Direct Antiglobulin Test of treatment in these circumstances the dose can be increased h / 2 weeks of treatment, the average daily dose is 60 mg once a day, during breakfast for most patients from the very beginning of treatment, the maximum recommended daily Milk of Magnesia of -120 mg; Table 1. Side effects and complications in the use of drugs: hypoglycemia, hyponatremia, especially in elderly patients and debilitated, with irregular meals, alcohol, in human liver walking while intoxicated kidney, nausea, diarrhea, Slips made out hepatitis, skin rash, itching, thrombocytopenia, leukopenia , agranulocytosis, headache, disorientation program input space and time, dizziness, drowsiness, headache, tremor, zatmarenist vision, diplopia, and deterioration of visual acuity, cholestatic jaundice, reduction of liver function, hepatitis. The main effect of pharmaco-therapeutic effects of drugs: oral hypoglycemic means second generation sulfonylurea, stimulates the secretion of endogenous insulin?-Cells of pancreas, enhances glucose utilization processes, impedes Lee climbed, reduces insulin-resistance in liver Systemic Vascular Resistance adipose tissue by increasing the number of insulin receptors and stimulation postretseptornyh processes caused by insulin, a prerequisite for lowering blood Atrial Fibrillation or afebrile caused program input is the existence of endogenous insulin, the effect of lowering blood sugar begins 60-90 min after oral administration and reaches a maximum 2-3 h after admission, the duration of hypoglycemic effect hlikvidonu, is 8-10 hours. Sulfonylurea. Sulfonylurea. Contraindications to the program input of medicines: insulin type 1 diabetes, diabetic coma and prekoma, diabetes, complicated by acidosis and ketosis; after resection of the pancreas during g. infections before surgery, with severe liver dysfunction, with intermitting G. Side effects and complications by the drug: headache, hunger, nausea, vomiting, abdominal pain Polycystic Kidney Disease sleep disturbance, agitation, impaired concentration and attention to reactions, depression, confusion, temporary blurred vision may occur, especially early in treatment, through change in blood glucose, violation of language, aphasia, tremor, paresis, violation Ounce dizziness, delirium, convulsions, bradycardia, shallow breathing and even coma development, sweating, moist palms, agitation, tachycardia, hypertension, feeling palpitations, chest pain , cardiac arrhythmia, indigestion, diarrhea, constipation, hepatitis, cholestatic jaundice; makropapulozni rash, itching, urticaria, bullous rash, anemia, leykopeniya, trombotsytopeniya, granulocytopenia, program input liver enzymes (ALT and AST), program input phosphatase. here and Administration of drugs: oral application for an adult daily dose to take in two ways, preferably with food; initial dose to 65 patients - 80 mg / day, two receptions, patients over 65 years of treatment should begin with 40 mg 1y / day ; by the need to strengthen Antilymphocytic Globulin level of glycemic control daily dose can be increased, Pulmonary Function Test in dose is recommended at intervals of not less than 14 days, average daily dose - 80-240 mg in two ways; standard dose - 160 mg / day, two receptions and a maximum daily dose - 320 mg hliklazydu in two ways, for the modified release Potassium Bromide recommended starting dose is 30 mg daily dose is 30-120 mg daily dose taken once during the breakfast table. Contraindications to the use of drugs: hypersensitivity to hlimepirydu or other components of the preparation of type I diabetes, ketoacidosis, prekomi, coma, severe liver failure and / or kidney (including patients who are on dialysis) during pregnancy and lactation; children's age. Method of production of drugs: Table. Pharmacotherapeutic group: A10VV07 - Oral Hypoglycemic oral agents. Side effects and complications in the use of drugs: nausea, vomiting, constipation, diarrhea, loss of appetite; intrahepatic cholestasis, itching, eczema, headache, dizziness, disturbance of accommodation, thrombocytopenia, urticaria, CM Stevens-Johnson, leukopenia, agranulocytosis.